We explored parameter uncertainty using a probabilistic sensitivity analysis of 1000 simulations of 1000 patients each, and calculated the mean and 95% credible interval for each model outcome. In clinical trials in adults with postherpetic neuralgia, 14% of patients treated with LYRICA and 7% of patients treated with placebo discontinued prematurely due to adverse reactions. In the LYRICA treatment group, the most common reasons for discontinuation due to adverse reactions were dizziness (4%) and somnolence (3%). In comparison, less than 1% of placebo patients withdrew due to dizziness and somnolence. Other reasons for discontinuation from the trials, occurring in greater frequency in the LYRICA group than in the placebo group, were confusion (2%), as well as peripheral edema, asthenia, ataxia, and abnormal gait (1% each).
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Taking this medication with other CNS depressants can make you too sleepy. CNS depressants include opioids, benzodiazepines, muscle relaxants, medications for sleep, and alcohol. Talk to your care team about all the medications, vitamins, and supplements you take. Call emergency services right away if you have slow or shallow breathing, feel dizzy or confused, or have trouble staying awake. Talk to your care team about the use of this medication in children.
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